iAluRil is a medical device presented in a prefilled syringe. The solution within the syringe is instilled directly into the bladder to help rebuild the damaged bladder lining.
It contains three active ingredients:
iAluRil can be used in the treatment of:
Bladder pain syndrome (BPS)
Recurrent urinary tract infections (rUTIs)*
Chemical/radiation-induced cystitis
(including BCG)
*iAluRil offers relief and prevention of rUTIs
As a healthy GAG layer is made of more than one component, it follows that an effective therapy will contain a combination. iAluRil is the only GAG therapy to contain both HA and CS; a combination which allows a more effective replenishment of the GAG layer.
Not only is iAluRil the only combination GAG therapy, it is also the only one to contain 3 components. The addition of calcium chloride (CaCl):
iAluRil has the most evidence of any GAG therapy, with the most clinical studies and high quality data from a range of different types of trials.⁶
These GAG components attach together and have the ability to bind water; forming a gel-like layer to protect inside of the bladder.
The addition of calcium chloride is what makes iAluRil different.
Calcium chloride stabilises the iAluRil solution and provides superior adhesive and protective properties.
The lining of the bladder is known as the glycosaminoglycan, or GAG layer. This layer protects the inside of the bladder from bacteria and the irritants found in urine. There are four components that make up the GAG layer, but the two present in iAluRil are hyaluronic acid and chondroitin sulphate.
In certain bladder conditions, like BPS/IC and rUTIs, the GAG layer becomes damaged which means the bladder lining is unprotected. This can cause irritation and damage; resulting in pain.
Nerve endings which are usually protected by the GAG layer may also become exposed; changing the signals sent to the brain about when to urinate; even a very small amount of urine in the bladder can feel like you’re about to burst.
The risk of infection is also higher.
Because iAluRil contains two GAG components; HA and CS, it is able to effectively replenish the damaged GAG layer. In doing so, the symptoms associated with bladder conditions; pain, urgency and frequency, may be alleviated and the risk of bacterial infection is significantly reduced .
iAluRil is available for patients to purchase following training either by a nurse
or by watching our self-administration videos.
We provide a range of useful information for patients;
from videos on self-administration to printable patient information.
A nurse advice line is also available for if you have any questions
Reference 1.
Horkay, Ferenc et al. “Chondroitin Sulfate in Solution: Effects of Mono- and Divalent Salts.” Macromolecules vol. 45,6 (2012): 2882-2890. doi:10.1021/ma202693
Reference 2.
Gribbon P, Heng BC, Hardingham TE. “The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain-chain association.’’ Biochem J. 2000 Aug 15;350 Pt 1:329-35.
Reference 3.
Stellavato, Antonietta et al. “Hyaluronic acid and chondroitin sulfate, alone or in combination, efficiently counteract induced bladder cell damage and inflammation.’’ ESSM Poster, Ljubljana 2019
Reference 4.
Zoppetti G, Puppini N, Pizzutti M. 2006 May 26; “Compositions comprising glycosaminoglycans of low viscosity and use of said composition in therapy of chronic cystitis’’ EP2034956B1
Reference 5.
Hurst, Robert E et al. “Functional and structural characteristics of the glycosaminoglycans of the bladder luminal surface’’ The Journal of Urology vol. 138 (1987) 0022-5347/87/1382-0433
Reference 6.
Damiano R, et al. Prevention of recurrent urinary tract infections by intravesical administration of hyaluronic Acid and
chondroitin sulphate: a placebo controlled randomised trial. Eur Urol. 2011 Apr; 59(4):64551. Epub 2011 Jan 18.
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