iAluRil treatment begins with a course of instillations given once a week for the first month.
The recommended dosage is then*:
one instillation every two weeks for the second month. In the following months, one instillation a month should be given until symptoms resolve to the satisfaction of both the clinician and patient.
From clinical trials, data has shown that further instillations can then be given at varying intervals dependent on the condition being treated:7
Painful Bladder Syndrome/ Interstitial Cystitis: at weeks 6 and 8.
Prevention of Urinary Tract Infections: monthly for 5 months.
Chemical induced cystitis (Including BCG): weekly for another 4 weeks.
Radiation induced cystitis: at weeks 6, 8 and 12.
Once the symptoms have improved, the interval between instillations can be increased slowly until you are happy that the regular doses are enough to keep symptoms under control. If the symptoms reoccur, the initial course of instillations can be repeated in order to settle the symptoms down again.
|Condition||Number of instillations||Administration regimen||Referred clinical work|
|Recurrent Urinary Tract Infection (rUTI)||9||Weekly for 4 weeks, then
monthly for 5 months
|Damiano et al 20111,
Cicione et al. 20142
|Painful Bladder Syndrome/ Interstitial Cystitis (PBS / IC)||6||Weekly for 4 weeks,
then at weeks 6 and 8*
|Chemical induced Cystitis (including BCG)||8||Weekly for 8 weeks||Imperatore et al. 20183,
Creta et al. 20124
|Radiation induced cystitis||7||Weekly for 4 weeks,
then at weeks 6, 8 and 12
|Gacci et al. 20165,
Giannessi et al. 20146
Method of administration
iAluRil is administered intravesically as a 50 ml bladder instillation via catheter (with Luer-Lock adapter) or using the ialuadapter®. Self-administration of iAluRil is permitted following appropriate training. Self help videos and nurse-led tutorials for both male and female patients are available on the patient website, in order to facilitate this training.
Administration via the catheter
Administration via the iAluadapter®
The iAluadapter® is an innovative device for catheter-free administration of iAluRil.®
Catheter-free GAG therapy
• Minimally invasive and practically pain free
• Enables simultaneous treatment of the urethral and bladder mucosa
• Low risk of infection
• Included in iAluRil® packs at no extra cost
Only licensed for use with iAluRil®